Friday, November 30, 2012

Talks to resume in LA-Long Beach harbors strike

Clerical workers picket in the rain at entrance to Pier 400 at the Port of Los Angeles Thursday, Nov. 29, 2012. Cargo ships were stacking up at the ports of Los Angeles and Long Beach as a strike by about about 70 clerical workers shut down most of the terminals that together are the nation's busiest port complex. Dockworkers were refusing to cross the picket lines even though an arbitrator ruled the walkout invalid on Tuesday. By Thursday morning, at least 18 ships docked and inside the adjacent harbors were not being serviced, port spokesmen said. (AP Photo/Nick Ut)

Clerical workers picket in the rain at entrance to Pier 400 at the Port of Los Angeles Thursday, Nov. 29, 2012. Cargo ships were stacking up at the ports of Los Angeles and Long Beach as a strike by about about 70 clerical workers shut down most of the terminals that together are the nation's busiest port complex. Dockworkers were refusing to cross the picket lines even though an arbitrator ruled the walkout invalid on Tuesday. By Thursday morning, at least 18 ships docked and inside the adjacent harbors were not being serviced, port spokesmen said. (AP Photo/Nick Ut)

The Maersk cargo terminal, where container-handling cranes are in the up and idle position, is seen at the Port of Los Angeles Thursday, Nov. 29, 2012. Cargo ships were stacking up at the ports of Los Angeles and Long Beach as a strike by about about 70 clerical workers shut down most of the terminals that together are the nation's busiest port complex. Dockworkers were refusing to cross the picket lines even though an arbitrator ruled the walkout invalid on Tuesday. By Thursday morning, at least 18 ships docked and inside the adjacent harbors were not being serviced, port spokesmen said. (AP Photo/Nick Ut)

A small group of clerical workers picket at the Maersk cargo terminal, where container-handling cranes are in the up and idle position, background, at the Port of Los Angeles Thursday, Nov. 29, 2012. Cargo ships were stacking up at the ports of Los Angeles and Long Beach as a strike by about about 70 clerical workers shut down most of the terminals that together are the nation's busiest port complex. Dockworkers were refusing to cross the picket lines even though an arbitrator ruled the walkout invalid on Tuesday. By Thursday morning, at least 18 ships docked and inside the adjacent harbors were not being serviced, port spokesmen said. (AP Photo/Nick Ut)

A clerical worker pickets in the rain at the Maersk cargo terminal, where container-handling cranes are in the up and idle position, background, at the Port of Los Angeles Thursday, Nov. 29, 2012. Cargo ships were stacking up at the ports of Los Angeles and Long Beach as a strike by about about 70 clerical workers shut down most of the terminals that together are the nation's busiest port complex. Dockworkers were refusing to cross the picket lines even though an arbitrator ruled the walkout invalid on Tuesday. By Thursday morning, at least 18 ships docked and inside the adjacent harbors were not being serviced, port spokesmen said. (AP Photo/Nick Ut)

(AP) ? Negotiators for employers and union workers at the Los Angeles and Long Beach harbors will resume talks following a third day of a strike that has shut down most of the terminals at the nation's busiest port complex, both sides confirmed Thursday.

Cargo ships had begun stacking up after seven of eight Los Angeles terminals and three of six Long Beach terminals were shuttered because 70 clerical workers went on strike. They were supported by dockworkers from their union who refused to cross their picket line.

The lead negotiator for the Los Angeles/Long Beach Harbor Employers Association Stephen Berry said he wrote a letter to the union president Thursday afternoon to invite him back to the negotiating table with no preconditions.

International Longshore and Warehouse Union spokesman Craig Merrilees confirmed a meeting would take place later Thursday to discuss the contract dispute clerical workers and 14 shippers have been locked in for 2? years.

By Thursday morning, at least 18 ships docked and inside the adjacent harbors were not being serviced, port spokesmen said.

"Basically, we're not moving cargo in and out here," Los Angeles port spokesman Phillip Sanfield said.

Talks broke off Monday and the workers struck at a single terminal but expanded the picket lines Wednesday, even after an arbitrator ruled the walkout invalid on Tuesday.

Combined, Los Angeles and Long Beach comprise the nation's busiest port complex, handling 40 percent of the nation's import trade.

There was no immediate word on how much the strike is costing the ports. November generally is a slower time for the ports because most holiday goods already have been shipped ashore.

However, there were concerns that a continued widespread strike could prompt retaliation from terminal operators. A bitter 10-day lockout at a number of West Coast ports in 2002 caused an estimated $15 billion in losses.

At issue is the union's contention that terminal operators have outsourced local clerical jobs out of state and overseas ? an allegation that the shippers deny.

Striking clerical worker Trinie Thompson, 41, said Thursday afternoon that her fellow strikers do work at computers ? such as collections, customer service and setting up container movement ? that can be handled from anywhere, and employers were taking advantage of that to use non-union workers overseas.

"We're definitely concerned about the outsourcing of jobs here," said Thompson, who added jobs were being sent to Costa Rica, India and Taiwan. "We need to keep the jobs here in the United States."

The negotiating group for the shippers has denied any local union clerical jobs were outsourced. The shippers, in turn, claim that the union wants contract language to permit "featherbedding" ? the practice of requiring employers to call in temporary employees and hire new permanent employees even when there is no work to perform.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2012-11-29-Port%20Strike/id-188e114b715341cc9da998cf9a7f0442

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Erkek Paketi Wants To Be The ?Manpacks Of Turkey? With Subscription Service For Mens Socks, Underwear & More

Screen shot3Strikingly similar to U.S. startup Manpacks, Turkey's Erkek Paketi offers a subscription e-commerce service that delivers men underwear, socks, t-shirts, shaving products and condoms on a monthly, two monthly or three monthly schedule. Like its North American inspiration, it's tapping into the preconception that men don't enjoy shopping -- at least not for dull purchases that need to be made on a semi-regular basis.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/mRImIb9XXXQ/

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Thursday, November 29, 2012

ScienceDaily: Gene News

ScienceDaily: Gene Newshttp://www.sciencedaily.com/news/health_medicine/genes/ Genes and Genetics News. Read today's medical research in genetics including what can damage genes, what can protect them, and more.en-usThu, 29 Nov 2012 15:31:38 ESTThu, 29 Nov 2012 15:31:38 EST60ScienceDaily: Gene Newshttp://www.sciencedaily.com/images/logosmall.gifhttp://www.sciencedaily.com/news/health_medicine/genes/ For more science articles, visit ScienceDaily.Proteins that work at the ends of DNA could provide cancer insighthttp://www.sciencedaily.com/releases/2012/11/121129152029.htm New insights into a protein complex that regulates the very tips of chromosomes could improve methods of screening anti-cancer drugs. Researchers determined the binding mechanism of proteins that protect and regulate telomeres, segments of repeating DNA units that cap the ends of chromosomes and a key target of cancer researchers.Thu, 29 Nov 2012 15:20:20 ESThttp://www.sciencedaily.com/releases/2012/11/121129152029.htmRoadmap to metabolic reprogramming for aginghttp://www.sciencedaily.com/releases/2012/11/121129130500.htm To survey previously uncharted territory, a team of researchers have created an "atlas" that maps more than 1,500 unique landmarks within mitochondria that could provide clues to the metabolic connections between caloric restriction and aging.Thu, 29 Nov 2012 13:05:05 ESThttp://www.sciencedaily.com/releases/2012/11/121129130500.htmBiology behind brain development disorder: Mutations in the gene, UBE3B, cause a rare genetic disorder in childrenhttp://www.sciencedaily.com/releases/2012/11/121129130406.htm A combination of sequencing and mouse models were used to identify the gene responsible for a brain developmental disorder seen in four patients. The study also shows that the biology uncovered in the mouse model helps to understand the symptoms in patients.Thu, 29 Nov 2012 13:04:04 ESThttp://www.sciencedaily.com/releases/2012/11/121129130406.htmCancer drug shows promise in eradicating latent HIV infectionhttp://www.sciencedaily.com/releases/2012/11/121129103543.htm Breakthrough drugs help people to live longer with HIV, but more research is needed for an actual cure. One challenge involves eradicating the virus when it is latent in the body. New research suggests the cancer drug, JQ1, may be useful in purging latent HIV infection by activating the virus in the presence of potent therapy -- essentially a dead end for the virus.Thu, 29 Nov 2012 10:35:35 ESThttp://www.sciencedaily.com/releases/2012/11/121129103543.htmMost of the harmful mutations in people arose in the past 5,000 to 10,000 yearshttp://www.sciencedaily.com/releases/2012/11/121129093951.htm A study of the age of more than 1 million single-letter variations in the human DNA code reveals that most of these mutations are of recent origin, evolutionarily speaking. They arose as a result of explosive population growth, which provides more chances for new mutations to appear in offspring. Many of these mutations are harmful, some have no effect, and others are beneficial now or may provide an adaptive advantage for future generations.Thu, 29 Nov 2012 09:39:39 ESThttp://www.sciencedaily.com/releases/2012/11/121129093951.htmRules devised for building ideal protein molecules from scratchhttp://www.sciencedaily.com/releases/2012/11/121129093949.htm By following certain rules, scientists can prepare architectural plans for building ideal protein molecules not found in the real world. Based on computer renditions, previously non-existent proteins can be produced from scratch in the lab. In our imperfect world, proteins can be beset by bulges, kinks, strains, and improperly buried parts, and many diseases arise from protein malformations. The researchers achieved a library of several ideal structures. The principles could aid in designing drugs, vaccines, industrial enzymes, fuels, and pollutant removers.Thu, 29 Nov 2012 09:39:39 ESThttp://www.sciencedaily.com/releases/2012/11/121129093949.htmImmune cells of the brain renew hopes for curing Alzheimer?s diseasehttp://www.sciencedaily.com/releases/2012/11/121129093132.htm A new experimental study carried out in mice shows that microglia, immune cells of the brain, might play a key role in protecting the brain from Alzheimer?s disease (AD). It is long believed that toxic sticky protein deposits in the brain called amyloid beta (Aβ) are responsible for loss of memory in AD patients. Earlier studies have shown that microglia can remove Aβ protein from the brain and therefore be vital for successful therapy. New research indicates that microglia may play a significant role irrespective of their capacity to remove brain Aβ deposits.Thu, 29 Nov 2012 09:31:31 ESThttp://www.sciencedaily.com/releases/2012/11/121129093132.htmRisk of childhood obesity can be predicted at birthhttp://www.sciencedaily.com/releases/2012/11/121128182739.htm A simple formula can predict at birth a baby?s likelihood of becoming obese in childhood, according to a new study.Wed, 28 Nov 2012 18:27:27 ESThttp://www.sciencedaily.com/releases/2012/11/121128182739.htmPonatinib acts against the most resistant types of chronic myeloid leukemiahttp://www.sciencedaily.com/releases/2012/11/121128182719.htm Phase I trial shows third-generation drug helps patients after other treatments fail.Wed, 28 Nov 2012 18:27:27 ESThttp://www.sciencedaily.com/releases/2012/11/121128182719.htmDouble duty: Immune system regulator found to protect brain from effects of strokehttp://www.sciencedaily.com/releases/2012/11/121128143549.htm A small molecule known to regulate white blood cells has a surprising second role in protecting brain cells from the deleterious effects of stroke, researchers report. The molecule, microRNA-223, affects how cells respond to the temporary loss of blood supply brought on by stroke -- and thus the cells' likelihood of suffering permanent damage.Wed, 28 Nov 2012 14:35:35 ESThttp://www.sciencedaily.com/releases/2012/11/121128143549.htmScientists pair blood test and gene sequencing to detect cancerhttp://www.sciencedaily.com/releases/2012/11/121128142651.htm Scientists have combined the ability to detect cancer DNA in the blood with genome sequencing technology in a test that could be used to screen for cancers, monitor cancer patients for recurrence and find residual cancer left after surgery.Wed, 28 Nov 2012 14:26:26 ESThttp://www.sciencedaily.com/releases/2012/11/121128142651.htmResearchers increase understanding of genetic risk factor for type 1 diabeteshttp://www.sciencedaily.com/releases/2012/11/121128132355.htm Researchers have demonstrated how a genetic variant associated with type 1 diabetes and other autoimmune diseases influences susceptibility to autoimmunity.Wed, 28 Nov 2012 13:23:23 ESThttp://www.sciencedaily.com/releases/2012/11/121128132355.htmHuman genetic variation recent, varies among populationshttp://www.sciencedaily.com/releases/2012/11/121128132259.htm Nearly three-quarters of mutations in genes that code for proteins -- the workhorses of the cell -- occurred within the past 5,000 to 10,000 years, fairly recently in evolutionary terms, said genomic and genetic experts.Wed, 28 Nov 2012 13:22:22 ESThttp://www.sciencedaily.com/releases/2012/11/121128132259.htmScientists uncover a novel cooperative effort to stop cancer spreadhttp://www.sciencedaily.com/releases/2012/11/121128122041.htm Scientists have uncovered a group of what have been considered relatively minor regulators in the body that band together to suppress the spread of cancer from its primary site.Wed, 28 Nov 2012 12:20:20 ESThttp://www.sciencedaily.com/releases/2012/11/121128122041.htmChanges in nerve cells may contribute to the development of mental illnesshttp://www.sciencedaily.com/releases/2012/11/121128122035.htm Reduced production of myelin, a type of protective nerve fiber that is lost in diseases like multiple sclerosis, may also play a role in the development of mental illness, according to new research.Wed, 28 Nov 2012 12:20:20 ESThttp://www.sciencedaily.com/releases/2012/11/121128122035.htmFirst success of targeted therapy in most common genetic subtype of non-small cell lung cancerhttp://www.sciencedaily.com/releases/2012/11/121128121505.htm Chemotherapy and a new, targeted therapy work better in combination than chemotherapy alone in treating patients with the most common genetic subtype of lung cancer, new research suggests.Wed, 28 Nov 2012 12:15:15 ESThttp://www.sciencedaily.com/releases/2012/11/121128121505.htmImmune system could play a central role in age-related macular degenerationhttp://www.sciencedaily.com/releases/2012/11/121128093919.htm Changes in how genes in the immune system function may result in age-related macular degeneration (AMD), the leading cause of visual impairment in older adults. The findings are epigenetic in nature, meaning that the underlying DNA is normal but gene expression has been modified, likely by environmental factors, in an adverse way. Environmental factors associated with AMD include smoking, diet, and aging. This is the first epigenetic study revealing the molecular mechanisms for any eye disease.Wed, 28 Nov 2012 09:39:39 ESThttp://www.sciencedaily.com/releases/2012/11/121128093919.htmMany flame retardants in house dust at unsafe levels, study findshttp://www.sciencedaily.com/releases/2012/11/121128093810.htm In a new study of the largest number of flame retardants ever tested in homes, researchers found that most houses had levels of at least one flame retardant that exceeded a federal health guideline.Wed, 28 Nov 2012 09:38:38 ESThttp://www.sciencedaily.com/releases/2012/11/121128093810.htmHow infidelity helps nieces and nephews: Men may share more genes with sisters' kids than cheating wife's kidshttp://www.sciencedaily.com/releases/2012/11/121127190021.htm A new study produced new mathematical support for a theory that explains why men in some cultures often feed and care for their sisters? children: where extramarital sex is common and accepted, a man?s genes are more likely to be passed on by their sister?s kids than by their wife?s kids.Tue, 27 Nov 2012 19:00:00 ESThttp://www.sciencedaily.com/releases/2012/11/121127190021.htmGene linked to respiratory distress in babieshttp://www.sciencedaily.com/releases/2012/11/121127130256.htm Some infants are more susceptible to potentially life-threatening breathing problems after birth, and rare, inherited DNA differences may explain why, according to new research.Tue, 27 Nov 2012 13:02:02 ESThttp://www.sciencedaily.com/releases/2012/11/121127130256.htmNew understanding of X chromosome inactivationhttp://www.sciencedaily.com/releases/2012/11/121127101534.htm Scientists have broadened our understanding of how cells regulate silencing of the X chromosome in a process known as X-inactivation.Tue, 27 Nov 2012 10:15:15 ESThttp://www.sciencedaily.com/releases/2012/11/121127101534.htmNew mechanism for cancer progression discoveredhttp://www.sciencedaily.com/releases/2012/11/121127094311.htm Researchers have discovered an alternative mechanism for activating rhe oncogene Ras that does not require mutation or hormonal stimulus.Tue, 27 Nov 2012 09:43:43 ESThttp://www.sciencedaily.com/releases/2012/11/121127094311.htmProtein injection points to muscular dystrophy treatmenthttp://www.sciencedaily.com/releases/2012/11/121127094248.htm Scientists have discovered that injecting a novel human protein into muscle affected by Duchenne muscular dystrophy significantly increases its size and strength, findings that could lead to a therapy akin to the use of insulin by diabetics.Tue, 27 Nov 2012 09:42:42 ESThttp://www.sciencedaily.com/releases/2012/11/121127094248.htmChemical 'switches' for neurodegenerative diseases discoveredhttp://www.sciencedaily.com/releases/2012/11/121127093951.htm Researchers have identified and ?switched off? a chemical chain that causes neurodegenerative diseases such as Huntington?s disease, amyotrophic lateral sclerosis and dementia. The findings could one day be of particular therapeutic benefit to Huntington?s disease patients.Tue, 27 Nov 2012 09:39:39 ESThttp://www.sciencedaily.com/releases/2012/11/121127093951.htmGene that causes tumor disorder linked to increased breast cancer riskhttp://www.sciencedaily.com/releases/2012/11/121127093855.htm New research showing a more than four-fold increase in the incidence of breast cancer in women with neurofibromatosis-1 (NF1) adds to growing evidence that women with this rare genetic disorder may benefit from early breast cancer screening with mammograms beginning at age 40, and manual breast exams as early as adolescence.Tue, 27 Nov 2012 09:38:38 ESThttp://www.sciencedaily.com/releases/2012/11/121127093855.htmMetabolic protein launches sugar feast that nurtures brain tumorshttp://www.sciencedaily.com/releases/2012/11/121126164003.htm PKM2 slips into nucleus to promote cancer; potential biomarker and drug approach discovered.Mon, 26 Nov 2012 16:40:40 ESThttp://www.sciencedaily.com/releases/2012/11/121126164003.htmPossible new treatment for Ewing sarcomahttp://www.sciencedaily.com/releases/2012/11/121126142855.htm Discovery of a new drug with high potential to treat Ewing sarcoma, an often deadly cancer of children and young adults, and the previously unknown mechanism behind it, come hand-in-hand in a new study.Mon, 26 Nov 2012 14:28:28 ESThttp://www.sciencedaily.com/releases/2012/11/121126142855.htmSurvival gene may be key to controlling HIV and hepatitishttp://www.sciencedaily.com/releases/2012/11/121126131349.htm A newly discovered gene that is essential for embryo survival could also hold the key to treating and potentially controlling chronic infections such as HIV, hepatitis and tuberculosis. The gene, called Arih2, is fundamental to the function of the immune system -- making critical decisions about whether to switch on the immune response to an infection.Mon, 26 Nov 2012 13:13:13 ESThttp://www.sciencedaily.com/releases/2012/11/121126131349.htmMicrobial 'missing link' discovered after man impales hand on tree branchhttp://www.sciencedaily.com/releases/2012/11/121126110737.htm Two years ago, a 71-year-old Indiana man impaled his hand on a branch after cutting down a dead tree. The wound caused an infection that led scientists to discover a new bacterium and solve a mystery about how bacteria came to live inside insects.Mon, 26 Nov 2012 11:07:07 ESThttp://www.sciencedaily.com/releases/2012/11/121126110737.htmTransposable elements reveal a stem cell specific class of long noncoding RNAshttp://www.sciencedaily.com/releases/2012/11/121125192838.htm Over a decade after sequencing the human genome, it has now become clear that the genome is not mostly ?junk? as previously thought. In fact, the ENCODE project consortium of dozens of labs and petabytes of data have determined that these ?noncoding? regions house everything from disease trait loci to important regulatory signals, all the way through to new types of RNA-based genes.Sun, 25 Nov 2012 19:28:28 ESThttp://www.sciencedaily.com/releases/2012/11/121125192838.htmNew molecular culprit linked to breast cancer progressionhttp://www.sciencedaily.com/releases/2012/11/121124090511.htm Researchers have uncovered a protein ?partner? commonly used by breast cancer cells to unlock genes needed for spreading the disease around the body. A report on the discovery details how some tumors get the tools they need to metastasize.Sat, 24 Nov 2012 09:05:05 ESThttp://www.sciencedaily.com/releases/2012/11/121124090511.htmNew insights into virus proteome: Unknown proteins of the herpesvirus discoveredhttp://www.sciencedaily.com/releases/2012/11/121123092132.htm The genome encodes the complete information needed by an organism, including that required for protein production. Viruses, which are up to a thousand times smaller than human cells, have considerably smaller genomes. Using a type of herpesvirus as a model system scientists have shown that the genome of this virus contains much more information than previously assumed. The researchers identified several hundred novel proteins, many of which were surprisingly small.Fri, 23 Nov 2012 09:21:21 ESThttp://www.sciencedaily.com/releases/2012/11/121123092132.htmScientists describe elusive replication machinery of flu viruseshttp://www.sciencedaily.com/releases/2012/11/121122152928.htm Scientists have made a major advance in understanding how flu viruses replicate within infected cells. The researchers used cutting-edge molecular biology and electron-microscopy techniques to ?see? one of influenza?s essential protein complexes in unprecedented detail. The images generated in the study show flu virus proteins in the act of self-replication, highlighting the virus?s vulnerabilities that are sure to be of interest to drug developers.Thu, 22 Nov 2012 15:29:29 ESThttp://www.sciencedaily.com/releases/2012/11/121122152928.htmProtein folding: Look back on scientific advances made as result of 50-year old puzzlehttp://www.sciencedaily.com/releases/2012/11/121122152910.htm Fifty years after scientists first posed a question about protein folding, the search for answers has led to the creation of a full-fledged field of research that led to major advances in supercomputers, new materials and drug discovery, and shaped our understanding of the basic processes of life, including so-called "protein-folding diseases" such as Alzheimer's, Parkinson's and type II diabetes.Thu, 22 Nov 2012 15:29:29 ESThttp://www.sciencedaily.com/releases/2012/11/121122152910.htmStep forward in regenerating and repairing damaged nerve cellshttp://www.sciencedaily.com/releases/2012/11/121121145638.htm Researchers recently uncovered a nerve cell's internal clock, used during embryonic development. This breakthrough could lead to the development of new tools to repair and regenerate nerve cells following injuries to the central nervous system.Wed, 21 Nov 2012 14:56:56 ESThttp://www.sciencedaily.com/releases/2012/11/121121145638.htmArchitecture of rod sensory cilium disrupted by mutationhttp://www.sciencedaily.com/releases/2012/11/121121145621.htm Using a new technique called cryo-electron tomography, scientists have created a three-dimensional map that gives a better understanding of how the architecture of the rod sensory cilium (part of one type of photoreceptor in the eye) is changed by genetic mutation and how that affects its ability to transport proteins as part of the light-sensing process.Wed, 21 Nov 2012 14:56:56 ESThttp://www.sciencedaily.com/releases/2012/11/121121145621.htmAging: Scientists further unravel telomere biologyhttp://www.sciencedaily.com/releases/2012/11/121121130933.htm Researchers have resolved the structure of that allows a telomere-related protein, Cdc13, to form dimers in yeast. Mutations in this region of Cdc13 put the kibosh on the ability of telomerase and other proteins to maintain telomeres.Wed, 21 Nov 2012 13:09:09 ESThttp://www.sciencedaily.com/releases/2012/11/121121130933.htmDrug resistance biomarker could improve cancer treatmenthttp://www.sciencedaily.com/releases/2012/11/121121130811.htm Cancer therapies often have short-lived benefits due to the emergence of genetic mutations that cause drug resistance. A key gene that determines resistance to a range of cancer drugs has been reported in a new study. The study reveals a biomarker that can predict responses to cancer drugs and offers a strategy to treat drug-resistant tumors based on their genetic signature.Wed, 21 Nov 2012 13:08:08 ESThttp://www.sciencedaily.com/releases/2012/11/121121130811.htmGenome packaging: Key to breast cancer developementhttp://www.sciencedaily.com/releases/2012/11/121121130703.htm Two recent studies delve into the role of chromatin modifying enzymes and transcription factors in tumour cells. In one, it was found that the PARP1 enzyme activated by kinase CDK2 is necessary to induce the genes responsible for the proliferation of breast cancer cells in response to progesterone. In another, extensive work has been undertaken to identify those genes activated by the administration of progesterone in breast cancer, the sequences that can be recognized and how these genes are induced.Wed, 21 Nov 2012 13:07:07 ESThttp://www.sciencedaily.com/releases/2012/11/121121130703.htmShort DNA strands in genome may be key to understanding human cognition and diseaseshttp://www.sciencedaily.com/releases/2012/11/121121130643.htm Previously discarded, human-specific ?junk? DNA represents untapped resource in the study of diseases like Alzheimer?s and autism.Wed, 21 Nov 2012 13:06:06 ESThttp://www.sciencedaily.com/releases/2012/11/121121130643.htmBiomarking time: Methylome modifications offer new measure of our 'biological' agehttp://www.sciencedaily.com/releases/2012/11/121121130633.htm In a new study, researchers describe markers and a model that quantify how aging occurs at the level of genes and molecules, providing not just a more precise way to determine how old someone is, but also perhaps anticipate or treat ailments and diseases that come with the passage of time.Wed, 21 Nov 2012 13:06:06 ESThttp://www.sciencedaily.com/releases/2012/11/121121130633.htmKidney tumors have a mind of their ownhttp://www.sciencedaily.com/releases/2012/11/121121104552.htm New research has found there are several different ways that kidney tumors can achieve the same result -- namely, grow.Wed, 21 Nov 2012 10:45:45 ESThttp://www.sciencedaily.com/releases/2012/11/121121104552.htmMechanism to repair clumped proteins explainedhttp://www.sciencedaily.com/releases/2012/11/121121104416.htm Clumped proteins can be dissolved with the aid of cellular repair systems -- a process of critical importance for cell survival especially under conditions of stress. Researchers have now decrypted the fundamental mechanism for dissolving protein aggregates that involves specific molecular chaperones.Wed, 21 Nov 2012 10:44:44 ESThttp://www.sciencedaily.com/releases/2012/11/121121104416.htmNovel mechanism through which normal stromal cells become cancer-promoting stromal cells identifiedhttp://www.sciencedaily.com/releases/2012/11/121121104401.htm New understanding of molecular changes that convert harmless cells surrounding ovarian cancer cells into cells that promote tumor growth and metastasis provides potential new therapeutic targets for this deadly disease, according to new research.Wed, 21 Nov 2012 10:44:44 ESThttp://www.sciencedaily.com/releases/2012/11/121121104401.htmNew test for tuberculosis could improve treatment, prevent deaths in Southern Africahttp://www.sciencedaily.com/releases/2012/11/121120194932.htm A new rapid test for tuberculosis (TB) could substantially and cost-effectively reduce TB deaths and improve treatment in southern Africa -- a region where both HIV and tuberculosis are common.Tue, 20 Nov 2012 19:49:49 ESThttp://www.sciencedaily.com/releases/2012/11/121120194932.htmEvolution of human intellect: Human-specific regulation of neuronal geneshttp://www.sciencedaily.com/releases/2012/11/121120194926.htm A new study has identified hundreds of small regions of the genome that appear to be uniquely regulated in human neurons. These regulatory differences distinguish us from other primates, including monkeys and apes, and as neurons are at the core of our unique cognitive abilities, these features may ultimately hold the key to our intellectual prowess (and also to our potential vulnerability to a wide range of 'human-specific' diseases from autism to Alzheimer's).Tue, 20 Nov 2012 19:49:49 ESThttp://www.sciencedaily.com/releases/2012/11/121120194926.htmRibosome regulates viral protein synthesis, revealing potential therapeutic targethttp://www.sciencedaily.com/releases/2012/11/121120132906.htm Rather than target RNA viruses directly, aiming at the host cells they invade could hold promise, but any such strategy would have to be harmless to the host. Now, a surprising discovery made in ribosomes may point the way to fighting fatal viral infections such as rabies.Tue, 20 Nov 2012 13:29:29 ESThttp://www.sciencedaily.com/releases/2012/11/121120132906.htmHow does antibiotic resistance spread? Scientists find answers in the nosehttp://www.sciencedaily.com/releases/2012/11/121120121835.htm Microbiologists studying bacterial colonization in mice have discovered how the very rapid and efficient spread of antibiotic resistance works in the respiratory pathogen, Streptococcus pneumoniae (also known as the pneumococcus). The team found that resistance stems from the transfer of DNA between bacterial strains in biofilms in the nasopharynx, the area just behind the nose.Tue, 20 Nov 2012 12:18:18 ESThttp://www.sciencedaily.com/releases/2012/11/121120121835.htmScientists identify inhibitor of myelin formation in central nervous systemhttp://www.sciencedaily.com/releases/2012/11/121120100155.htm Scientists have discovered another molecule that plays an important role in regulating myelin formation in the central nervous system. Myelin promotes the conduction of nerve cell impulses by forming a sheath around their projections, the so-called axons, at specific locations -- acting like the plastic insulation around a power cord.Tue, 20 Nov 2012 10:01:01 ESThttp://www.sciencedaily.com/releases/2012/11/121120100155.htm'Obese but happy gene' challenges the common perception of link between depression and obesityhttp://www.sciencedaily.com/releases/2012/11/121120084725.htm Researchers have discovered new genetic evidence about why some people are happier than others. The scientists have uncovered evidence that the gene FTO -- the major genetic contributor to obesity -- is associated with an eight per cent reduction in the risk of depression. In other words, it's not just an obesity gene but a "happy gene" as well.Tue, 20 Nov 2012 08:47:47 ESThttp://www.sciencedaily.com/releases/2012/11/121120084725.htmTelomere lengths predict life expectancy in the wild, research showshttp://www.sciencedaily.com/releases/2012/11/121119213144.htm Researchers have found that biological age and life expectancy can be predicted by measuring an individual's DNA. They studied the length of chromosome caps -- known as telomeres -- in a 320-strong wild population of Seychelles Warblers on a small isolated island.Mon, 19 Nov 2012 21:31:31 ESThttp://www.sciencedaily.com/releases/2012/11/121119213144.htmCancer: Some cells don't know when to stophttp://www.sciencedaily.com/releases/2012/11/121119171403.htm Certain mutated cells keep trying to replicate their DNA -- with disastrous results -- even after medications rob them of the raw materials to do so, according to new research.Mon, 19 Nov 2012 17:14:14 ESThttp://www.sciencedaily.com/releases/2012/11/121119171403.htmMultiple sclerosis ?immune exchange? between brain and blood is uncoveredhttp://www.sciencedaily.com/releases/2012/11/121119163301.htm DNA sequences obtained from a handful of patients with multiple sclerosis have revealed the existence of an ?immune exchange? that allows the disease-causing cells to move in and out of the brain.Mon, 19 Nov 2012 16:33:33 ESThttp://www.sciencedaily.com/releases/2012/11/121119163301.htmFruit fly studies guide investigators to molecular mechanism frequently misregulated in human cancershttp://www.sciencedaily.com/releases/2012/11/121119132056.htm Changes in how DNA interacts with histones ?- the proteins that package DNA ?- regulate many fundamental cell activities from stem cells maturing into a specific body cell type or blood cells becoming leukemic. These interactions are governed by a biochemical tug of war between repressors and activators, which chemically modify histones signaling them to clamp down tighter on DNA or move aside and allow a gene to be expressed.Mon, 19 Nov 2012 13:20:20 ESThttp://www.sciencedaily.com/releases/2012/11/121119132056.htm3-D light switch for the brain: Device may help treat Parkinson's, epilepsy; aid understanding of consciousnesshttp://www.sciencedaily.com/releases/2012/11/121119114249.htm A new tool for neuroscientists delivers a thousand pinpricks of light to individual neurons in the brain. The new 3-D "light switch", created by biologists and engineers, could one day be used as a neural prosthesis that could treat conditions such as Parkinson's and epilepsy by using gene therapy to turn individual brain cells on and off with light.Mon, 19 Nov 2012 11:42:42 ESThttp://www.sciencedaily.com/releases/2012/11/121119114249.htmNew factor of genetic susceptibility to Alzheimer's diseasehttp://www.sciencedaily.com/releases/2012/11/121119104944.htm A large-scale international study has just discovered a gene for susceptibility to a rare disease providing evidence of the heterogeneous aetiology of Alzheimer's disease.Mon, 19 Nov 2012 10:49:49 ESThttp://www.sciencedaily.com/releases/2012/11/121119104944.htmBlood cancer gene BCL6 identified as a key factor for differentiation of nerve cells of cerebral cortexhttp://www.sciencedaily.com/releases/2012/11/121119093848.htm The cerebral cortex is the most complex structure in our brain and the seat of consciousness, emotion, motor control and language. In order to fulfill these functions, it is composed of a diverse array of nerve cells, called cortical neurons, which are affected by many neurological and neuropsychiatric diseases. Researchers have opened new perspectives on brain development and stem cell neurobiology by discovering a gene called BCL6 as a key factor in the generation of cortical neurons during embryonic brain development.Mon, 19 Nov 2012 09:38:38 ESThttp://www.sciencedaily.com/releases/2012/11/121119093848.htmMinority report: Insight into subtle genomic differences among our own cellshttp://www.sciencedaily.com/releases/2012/11/121118141530.htm Scientists have demonstrated that induced pluripotent stem cells -- the embryonic-stem-cell look-alikes whose discovery a few years ago won this year's Nobel Prize in medicine -- are not as genetically unstable as was thought.Sun, 18 Nov 2012 14:15:15 ESThttp://www.sciencedaily.com/releases/2012/11/121118141530.htmSkin cells reveal DNA's genetic mosaichttp://www.sciencedaily.com/releases/2012/11/121118141524.htm The prevailing wisdom has been that every cell in the body contains identical DNA. However, a new study of stem cells derived from the skin has found that genetic variations are widespread in the body's tissues, a finding with profound implications for genetic screening.Sun, 18 Nov 2012 14:15:15 ESThttp://www.sciencedaily.com/releases/2012/11/121118141524.htmLikely basis of birth defect causing premature skull closure in infants identifiedhttp://www.sciencedaily.com/releases/2012/11/121118141432.htm Geneticists, pediatricians, surgeons and epidemiologists have identified two areas of the human genome associated with the most common form of non-syndromic craniosynostosis premature closure of the bony plates of the skull.Sun, 18 Nov 2012 14:14:14 ESThttp://www.sciencedaily.com/releases/2012/11/121118141432.htm

Source: http://www.sciencedaily.com/rss/health_medicine/genes.xml

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Is Washington Ready For a Carbon Tax?

Video and PowerPoints are now available from
The Wesleyan Conference
November 2010

Watch the 30-minute highlight video

Watch the 3-minute trailer

See presentations (video and PPT) by Hansen, McKibben, Ackerman, Yohe, Barnes, DeChristopher, Kamarck, Reps. Larson, McDermott, Inglis & Filner, and others; plus Q&A.

Source: http://www.carbontax.org/blogarchives/2012/11/28/is-washington-ready-for-a-carbon-tax/

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There has been an error of some kind. Ack!

Sorry, Readability was unable to parse this page for content.

Source: http://feeds.feedburner.com/googlemoneyscam

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Wednesday, November 28, 2012

How to set reminders and update task and to-do lists with Siri

Complete guide to Siri commands for Reminders, tasks, and to-do lists

Siri was designed to help you get things done, and part of that job description is creating and updating your to-dos and lists of to-dos in the Reminders app of your iPhone 5, iPhone 4S, iPod touch 5, iPad 4, iPad 3, and iPad mini. If you need to be prodded to pick up milk on the way home, order that present in time for the big party, or set up that lunch meeting before the end of the day, Siri's there to help.

(Unfortunately, you can't delete tasks or mark items as completed using Siri (at least not yet), so you still have to launch the Reminders app for that.)

How to create a time-based reminder with Siri

One of the easiest things to do with Siri is have it set up a quick Reminder. Siri is so quick, in fact, it's almost always faster to use Siri than to tap your way through the Reminders app to set them up manually.

  1. Press and hold down the Home button to activate Siri.
  2. Tell Siri what you want to be reminded about, and when. For example: "Remind me to call Leanna at 9pm."
  3. Tap Confirm to set the reminder.

The Reminder will go into the default Reminders list. This is usually Reminders for iCloud users and Tasks for Exchange users, or whatever you set up as the default list in Settings.

If you made a mistake or simply want to revise something immediately, instead of confirming, you can also tell Siri to "change the time to", "change the title (of the appointment/event)", or simply "cancel" it entirely.

Tap the Reminders widget to quickly mark the Reminder as completed.

How to create a location-based reminder with Siri

Because your iOS device knows where you are, you can set up Reminders based on location as well. Again, it's much faster to do this with Siri than manually through the Reminders app.

  1. Hold down the Home button to activate Siri.
  2. Tell Siri what you want to be reminded about, and where. For example: "Remind me to pay my credit card bill when I get home" or "remind me to troll Rene when I get to work".
  3. Tap Confirm to set the Reminder.

Just like with standard Reminders, the location Reminder will go into the default Reminders list. This is usually Reminders for iCloud users and Tasks for Exchange users, or whatever you set up as the default list in Settings.

If you made a mistake or simply want to revise something immediately, instead of confirming, you can also tell Siri to "change the time to", "change the title (of the appointment/event)", or simply "cancel" it entirely.

If you tap the Reminders widget, you can mark the Reminder as completed.

How to create a Reminder in a specific List with Siri

If you have multiple lists in Reminders, like a packing list, a party list, etc. you can tell Siri to create a to-do item specifically for one of those lists.

  1. Press and hold down the Home button to activate Siri.
  2. Tell Siri what you want to be reminded about, and in which List you want it to go. For example: "Add sun tan lotion to my packing list."
  3. Tap Confirm to set the Reminder.

Now the Reminder will be placed in the List you specified.

If you forget to specify a list when you create your Reminder, you can still move it before you confirm the Reminder.

  1. Press and hold down the Home button to activate Siri.
  2. Tell Siri to create a reminder. (See above.)
  3. When Siri asks for confirmations, immediately tell Siri which list you'd like the Reminder to be placed in. For example: "Move it to my iMore list."
  4. Tap Confirm to set the Reminder.

The Reminder will then be placed in the List you specified.

How to maintain a shared shopping list with Siri and iCloud

Siri in conjunction with the default Reminders app is a great way to maintain shopping lists, and when combined with iCloud, shared shopping lists. You can have one general shopping list, or even specific shopping lists, like a grocery list.

Before you can use Siri to add items to a grocery or any other list, you first have to create them in the Reminders app, and set up the sharing in iCloud.

Once you have the list setup, just add items to it like you would any list.

  1. Hold down the Home button to activate Siri.
  2. Tell Siri what you want to add and to which shopping list. For example: "Add cake to my shopping list."
  3. Tap Confirm to set the Reminder.

Now anyone you share the list with can add items whenever you think of something, and all of you see them next time you're out shopping. When an item is taken care of and marked as done, everyone sees it marked as done as well.

How to get more help with Siri

If you still need help with setting up or using Siri with your iPhone Contacts, or any other Siri feature, head on over to our Siri Forum and ask away!



Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/y1TWGGYIlN4/story01.htm

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Tuesday, November 27, 2012

jomlusingh2563: ramgopall987456ramgopall987456: Hobby Lobby ...


Added: 6 hours ago
via: Android Market
Category: Lifestyle
By: Hobby Lobby...
Updated: November 15, 2012
????? 60 ratings
Requires Android 2.3.3 and up

Now you can take Hobby Lobby with you wherever you go! Download our new Android app to get the latest coupon, see the weekly savings, locate stores near you, check your gift card balance, and much more! The weekly savings and convenience you have come to love is now just a tap away.
We are not just an arts and crafts store. With over 65,000 items to explore including Home Accents, Crafts, Hobbies, Picture Framing, Jewelry Making, Fashion Fabrics, Floral, Cards & Party, Baskets, Wearable Art and Holiday Supplies, Hobby Lobby is the place to shop with super savings and super selections every day!
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What?s in this version:

- Bug fixes

Source: http://appaggie.com/2012/11/18/hobby-lobby-stores/

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GM gets Siri-ous about voice-activated tech

7 hrs.

General Motors is getting Siri-ous about its voice-activated infotainment technology.? The maker plans to introduce the Apple iPhone?s popular voice-activated personal assistant technology on three of its Chevrolet models early next year.

The technology will allow a motorist to do many of the things already found in older, less advanced voice-controlled in-car technologies, such as playing music, switching radio stations or plugging in a destination. But Siri was designed to go even further, providing access to an iPhone contact, for example, or checking or adding appointments and even finding a local business, store or restaurant.

?Safe, easy, reliable and portable connectivity is a top priority for our customers and Siri complements MyLink?s existing capabilities to help deliver an incredible driving experience,? said Cristi Landy, Chevrolet?s small car marketing director, referring to the brand?s current infotainment technology.

The technology will be offered in the conventionally powered Chevrolet Sonic subcompact and Spark minicar, as well as the new 2014 Spark EV battery-electric vehicle.? It will connect to MyLink via those vehicles? Bluetooth technology. And GM will now place a special Siri activation button on the steering wheel, similar to the button many vehicles already have to activate conventional voice-controlled technologies.

The three models appeal to a typically youthful, tech-savvy audience and GM estimates as much as 90 percent of their buyers have smartphones already. But Siri could be integrated later into other models. The maker has also announced plans to add a next-generation version of the ChevyMyLink system to the upcoming remake of its big Impala.

Apple introduced Siri on the last version of its iPhone 4 series and it is standard on all new iPhone 5 models. The maker has also indicated its interest in working with manufacturers to get the feature integrated into vehicles by the addition of a dedicated ?Siri button,? but marketing manager Landy boasted that, ?Chevrolet has announced that Siri Eyes Free capability will be available in the Spark and Sonic well before the luxury brands

The Eyes Free mode will block still more complex activities that might prove to be a distraction, such as those that would require a motorist to look at the phone or the car?s video screen to take action.

Distracted driving has become a major concern among safety advocates, U.S. Department of Transportation Chief Ray LaHood recently estimating as much as 11 percent of all highway fatalities may be linked to roadway distractions such as texting. Proponents, however, insist that voice controlled technologies, such as Siri, can reduce distracted driving.

Other automakers, including Mercedes-Benz, Chrysler, Honda and Toyota are reportedly working with Apple to add Siri capability. Mercedes-Benz has already announced a voice-control feature it has described as iPhone-like, though it has not confirmed plans to add a Siri button.

Infotainment technology, especially those allowing voice control, have become all but essential for automakers hoping to appeal to buyers in the digital age.

?We have more people coming to Ford because they know we have better infotainment technology,? said Jim Farley, Ford Motor Co.?s global marketing director, during an interview with TheDetroitBureau.com.

Ford was one of the early pioneers of the technology with its Sync system which was developed through a partnership with Microsoft. But it has also discovered that infotainment systems can be both good news and bad.? The maker has taken sharp hits from consumers and critics alike for problems in operating its in-car technologies. Ford this week announced an updated version of its MyFordTouch system for the 2014 Fiesta minicar that should be easier to use.

A critical goal for makers is to simplify the operation of such technologies, with an emphasis on allowing motorists to use conventional speech rather than having to learn rigid command language that might require a series of steps to perform an otherwise simple process like pairing a smartphone.

Along with the Siri feature, the Chevy MyLink system is expanding its ability to integrate various smartphone apps to access a motorist?s choice of music, for example. And in another potential breakthrough, some Chevrolet models can link to the BringGo navi app. Based on a smartphone, it is available for just $50, a fraction of the cost for a typical in-car navigation system.

More from The Detroit Bureau

Source: http://www.nbcnews.com/business/gm-gets-siri-ous-about-voice-activated-technology-1C7284866

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How to overcome your fear of marriage - All4Women Relationship ...

How to overcome your fear of marriage

With divorce rates being what they are and people living well into their 70s, 80s, and 90s, tying the knot might seem more intimidating than ever. However, by understanding what marriage entails and clarifying your expectations, you can overcome your nuptial-phobia and make an informed decision on whether or not to get married.

1.? Try to determine what exactly are your fears of marriage

Most people don't fear marriage itself but rather, its implications and its potential failure. What are you worried will change? What's the worst possible scenario that's paralysing your views on marriage?

2.? Address your fears of marriage

If your parents had a bad marriage, understand that every marriage is different. If you're worried about your marriage falling apart, make a list in your mind of what you can and will do to make the marriage work. Imagine all the scenarios that make you scared and then, imagine what you will do in that specific situation to make it better.

Consider that if you allow your fear of marriage to prevent you from settling down, you might be single for the rest of your life. Make sure that's a risk you're willing to take, and accept responsibility for.

3.? Re-evaluate your failed past relationships

It can also help to re-evaluate your failed relationships. How or where did they go wrong? Talk with your significant other about their past relationships and try to determine why those did not work out. Understanding what went wrong in the past can help you avoid the same issues this time around.

4.? Chat with those in a successful marriage

Ask anybody in a successful marriage to tell you their secrets, and discuss this with your partner. This is the perfect opportunity to exercise the communication skills that are essential for any healthy relationship to last. An understanding and helpful partner will also help you to overcome your fear of marriage.

5.? Decide whether you?ve chosen the right person

Decide whether the person you have chosen is the one with whom you want to spend the rest of your life. Or, have they chosen you and you're now being pressured into marriage?

It might not be marriage itself that you fear, but marriage to this person. It?s wise not to marry the person you know you can live with for the rest of your life ? rather marry the one whom you can't imagine living without.

6.? Accept that marriage has its ups and downs

Realise that you are not going to live in harmony every second of every day. If this is your expectation, you'll never settle down or get married because no one will ever be able to live up to that illusion.

Marriage is hard work and no marriage is perfect. Too many people get married with the idea that, should things start to get tough, they'll just file for divorce and start all over again. Be prepared for the bumps in the road, and don't be surprised when you come across them.

7.? Plan your future life together to overcome your fear of marriage

Sit down and sort out some things before you get married. Will you have children? If so, how many? Who will manage the money? Will both spouses work? How much will you save for retirement? Where will you live? Who gets which responsibility? What about religion issues? If the husband can still go out to bars with his buddies, can the wife still do the same?

These are the difficult yet practical questions to ask before you commit yourself to somebody for the rest of your life. It's better to foresee conflict and prevent it. If you have a healthy relationship, the questioning process will bring you closer.

8.? Do some introspection about sexual exclusivity

Many people have healthy and happy committed relationships which include clear agreements on sexual privacy without sexual exclusivity. Don?t let societal standards dictate what makes you and your mate happy. Many people are afraid of the prospect of lifelong sexual exclusivity.

Article provided by wikiHow, a wiki building the world's largest, highest quality how-to manual. Please edit this article and find author credits at the original wikiHow article on How to overcome your fear of marriage. Content on wikiHow can be shared under a Creative Commons License.

Don't miss out! Subscribe to our free Relationship Tips Newsletter.

Source: http://all4women.co.za/love-and-relationships/relationship-articles/how-to-overcome-your-fear-of-marriage.html

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'Twilight,' Bond, 'Lincoln' lead record weekend

FILE - In this Thursday, Nov. 15, 2012 file photo, from left, American actor Taylor Lautner, American actress Kristen Stewart and British actor Robert Pattinson pose during a photo call at the Spanish premiere of the film "The Twilight Saga: Breaking Dawn-Part 2" in Kinepolis Cinema in Madrid, Spain. Stewart, Pattinson and Lautner have walked their last ?Twilight? red carpet with the arrival of the finale ?The Twilight Saga: Breaking Dawn - Part 2,? and now must step into careers of their own using the superstardom the multi-billion-dollar franchise has provided them. ( AP Photo/Gabriel Pecot, File)

FILE - In this Thursday, Nov. 15, 2012 file photo, from left, American actor Taylor Lautner, American actress Kristen Stewart and British actor Robert Pattinson pose during a photo call at the Spanish premiere of the film "The Twilight Saga: Breaking Dawn-Part 2" in Kinepolis Cinema in Madrid, Spain. Stewart, Pattinson and Lautner have walked their last ?Twilight? red carpet with the arrival of the finale ?The Twilight Saga: Breaking Dawn - Part 2,? and now must step into careers of their own using the superstardom the multi-billion-dollar franchise has provided them. ( AP Photo/Gabriel Pecot, File)

FILE - This Oct. 22, 2012 file photo shows British actor Robert Pattinson, right, having his photo taken with fans upon arrival for an exclusive fan event for the final chapter of the Twilight Saga "Breaking Dawn Part 2" in Sydney, Australia. Thanksgiving newcomers have been unable to knock off the big three at the box office: Bella, Bond and Abe Lincoln. Kristen Stewart's finale as Bella Swan led the holiday weekend ticket sales. (AP Photo/Rob Griffith, File)

(AP) ? Bella Swan, James Bond and Abe Lincoln have combined to lift Hollywood to record Thanksgiving revenue at the box office.

Kristen Stewart's finale as Bella in "The Twilight Saga: Breaking Dawn ? Part 2" was No. 1 again with $64 million during the five-day holiday stretch that began Wednesday, according to studio estimates Sunday.

Daniel Craig's Bond adventure "Skyfall" came in at No. 2 with $51 million, while Daniel Day-Lewis and Steven Spielberg's Civil War saga "Lincoln" finished third with $34.1 million.

According to box-office tracker Hollywood.com, the three films paced Hollywood to an all-time Thanksgiving week best of about $290 million from Wednesday to Sunday.

That tops the previous record of $273 million over Thanksgiving in 2009, when "The Twilight Saga: New Moon" led the weekend.

This Thanksgiving also was a huge 25 percent jump from a year ago, when domestic revenues were a weak $232 million as some big holiday releases fizzled.

With a strong December lineup ahead, Hollywood has resumed its record revenue pace for the year after a brief box-office lull in late summer and early fall.

Domestic revenues for 2012 are at $9.75 billion, putting Hollywood potentially on track for its first $11 billion year, which would beat the 2009 record of $10.6 billion, said Hollywood.com analyst Paul Dergarabedian.

"We're barreling toward a record-breaking box-office year," Dergarabedian said. "It's built on the back of just a lot of really strong movies that have come out over the past few weekends. It bodes very well for the rest of the holidays."

The "Twilight" finale, "Skyfall" and "Lincoln" finished in the same top-three rankings for the second-straight weekend as new releases were unable to dislodge the holdovers.

Released by Lionsgate's Summit Entertainment banner, "Breaking Dawn ? Part 2," pulled in $43.1 million from Friday to Sunday, raising its domestic total to $227 million. The movie added $97.4 million overseas to bring its international total to $350.8 million and its worldwide take to $577.7 million.

Sony's "Skyfall" also topped $200 million domestically, ringing up $36 million for the three-day weekend to put its U.S. total at $221.7 million. With $41.3 million more overseas, "Skyfall" raised its international revenues to $568.4 million and its worldwide sales to $790.1 million.

"Lincoln," a DreamWorks film distributed by Disney, took in $25 million over the weekend to lift its domestic revenue to $62.2 million.

Leading the newcomers was Paramount and DreamWorks Animation's tale "Rise of the Guardians" at No. 4 with $24 million for the weekend and $32.6 million since opening Wednesday.

Based on William Joyce's "Guardians of Childhood" books, "Rise of the Guardians" gathers Santa Claus, the Easter Bunny, the Tooth Fairy and other mythical beings as a team of heroes battling an evil overlord.

Close behind at No. 5 was director Ang Lee's shipwreck saga "Life of Pi" at No. 5 with $22 million over the weekend. The 20th Century Fox release has taken in $30.2 million domestically since its Wednesday debut and added $17.5 million in four Asian markets.

"Life of Pi" was adapted from Yann Martel's best-selling novel about an Indian youth adrift on a lifeboat with a Bengal tiger. Many fans considered the introspective novel impossible to film, but Lee has charmed audiences and critics with an inspiring survival story told through dazzling 3-D images.

The weekend's other new wide release, a remake of the 1980s U.S.-invasion tale "Red Dawn," opened at No. 7 with $14.6 million, raising its total to $22 million since debuting Wednesday.

"Red Dawn" sat on the shelf for three years while studio backer MGM went through bankruptcy, with distributor FilmDistrict eventually picking it up for domestic release. The movie's cast includes Chris Hemsworth ("Thor") and Josh Hutcherson ("The Hunger Games") in a story of young guerrillas battling North Korean invaders.

In limited release, Fox Searchlight's "Hitchcock" opened solidly with about $300,000 in 17 theaters. The movie stars Anthony Hopkins as Alfred Hitchcock in a behind-the-scenes story of the making of "Psycho."

The weekend's overall strength came from a broad range of films that clicked with various audiences, from action and family fare to thoughtful drama.

"This is a marketplace that has something for everyone," said Chris Aronson, head of distribution for 20th Century Fox. "You have something deeper like 'Life of Pi,' yet you have a very successful sequel in 'Twilight' at the same time. Adult bio-drama, if you will, in 'Lincoln,' and you have Bond. That's the secret to a very successful and balanced marketplace."

Estimated ticket sales for Friday through Sunday at U.S. and Canadian theaters, according to Hollywood.com. Where available, latest international numbers are also included. Final domestic figures will be released Monday.

1. "The Twilight Saga: Breaking Dawn ? Part 2," $43.1 million ($97.4 million international).

2. "Skyfall," $36 million ($41.3 million international).

3. "Lincoln," $25 million.

4. "Rise of the Guardians," $24 million.

5. "Life of Pi," $22 million ($17.5 million international)

6. "Wreck-It Ralph," $16.8 million ($2.1 million international).

7. "Red Dawn," $14.6 million.

8. "Flight," $8.6 million.

9. "Silver Linings Playbook," $4.6 million.

10. "Argo," $3.9 million.

___

Online:

http://www.hollywood.com

http://www.rentrak.com

___

Universal and Focus are owned by NBC Universal, a unit of Comcast Corp.; Sony, Columbia, Sony Screen Gems and Sony Pictures Classics are units of Sony Corp.; Paramount is owned by Viacom Inc.; Disney, Pixar and Marvel are owned by The Walt Disney Co.; Miramax is owned by Filmyard Holdings LLC; 20th Century Fox and Fox Searchlight are owned by News Corp.; Warner Bros. and New Line are units of Time Warner Inc.; MGM is owned by a group of former creditors including Highland Capital, Anchorage Advisors and Carl Icahn; Lionsgate is owned by Lions Gate Entertainment Corp.; IFC is owned by AMC Networks Inc.; Rogue is owned by Relativity Media LLC.

Associated Press

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Monday, November 26, 2012

Statement Against High-Stakes Standardized Testing by ...

DEY?s Senior Adviser, Nancy Carlsson-Piage recently initiated a Statement against High- Stakes Testing? which is being signed by Massachusetts professors and researchers.? Below, read a ?call to action? letter aimed at all Massachusetts professors and researchers, explaining the why it is important and how to sign on.

Dear Professor,

There is a new sense of possibility for change in our outmoded high-stakes testing policies, thanks to a growing national movement of educators, parents and students. A National Resolution on High-Stakes Testing has gained more than 13,600 individual and 460 organizational signers. Thanks in large part to testing fiascos around the country, the mainstream press has started to take note and editorials have begun to question this approach to education ?reform.?

Inspired by recent statements by education professors in New York and Chicago, we have written a Massachusetts version of a statement against high-stakes testing that we hope would draw similarly large numbers of signers (New York?s has 1,160 ? http://www.nyclu.org/files/releases/testing_professor_letter.pdf; Chicago?s has 88 ? http://createchicago.blogspot.com/2012_02_01_archive.html; a new letter from Georgia professors has 38 ? http://www.empoweredga.org/Articles/greater-support.html).

We would greatly appreciate it if you would take the time to review this letter and consider endorsing it. If you are willing to sign this statement, please send an email to matestingstatement@gmail.com with the heading ?I Will Sign On? and your name and position in the body of the email. And if you do endorse it, will you help us reach additional signers? These could be colleagues at your college or at another college, in schools of education or in other departments.

Attached to this message is a copy of the statement with a list of the 32 original endorsers and four initiators.

Sincerely,

?Chris Buttimer, Ed.D. candidate, Harvard Graduate School of Education

Nancy Carlsson-Paige, Professor Emerita, Lesley University

Lisa Guisbond, FairTest and Citizens for Public Schools

Monty Neill, Executive Director, FairTest

Below?read the statement in its entirety:

Statement against High-Stakes Standardized Testing

by Massachusetts Professors and Researchers

There has been a ground swell of opposition to the overuse and misuse of standardized testing across the United States. This includes statements from more than 670 Texas school boards, nearly one-third of all New York State principals, and hundreds of organizations and thousands of individuals who have endorsed the National Resolution on High-Stakes Testing. Against this backdrop, two significant statements have come from groups of educators and researchers in Chicago, Georgia and New York.We applaud these actions and have come together in solidarity with their efforts.

We respectfully present this statement to the Massachusetts Commissioner of Education, the Secretary of Education and the Board of Elementary and Secondary Education (BESE) because you have it within your power to dramatically improve state assessment policies and thereby improve the learning opportunities and conditions for all of our students.? We also copy this to the Governor and key legislators, as they too have the power to enact positive changes.

As educators and researchers from across the Commonwealth of Massachusetts, we strongly oppose our state?s continued overreliance on high-stakes standardized testing to assess student achievement, evaluate teacher effectiveness, and determine school quality. Given that standardized tests provide only one indicator of student achievement, and that their high-stakes uses produce ever-increasing incentives to teach to the test, narrow the curriculum, or even to cheat, we call on the BESE to stop using standardized tests in high-stakes decisions affecting students, teachers, and schools.

Researchers have documented, and a nine-year study by the National Research Council (Hout & Elliott, 2011) has confirmed, that the past decade?s emphasis on testing has yielded little learning progress. Further, testing experts and the test-makers themselves have consistently warned against using standardized tests for high-stakes decisions such as graduation or retention, or to hire, fire, or reward teachers (AERA, 2000).? The tests provide only a snapshot of a limited range of knowledge and skills, so they can provide only limited information to teachers. Because the tests are not designed to determine teacher effectiveness, no accurate conclusions can be drawn about an individual teacher from her students? test scores. Research indicates that a teacher?s impact on student learning cannot be reliably isolated from the myriad other factors that impact student learning (Baker et al., 2009). Finally, test experts have shown that test scores can be raised without increasing true student learning (Koretz, 2008), and that the higher the stakes attached to a test, the less trustworthy the test scores are.? Cheating scandals in Atlanta, Washington, D.C., and dozens of other major cities dramatically illustrate this problem. Problems with the use of MCAS interact with other educational problems, such as continued funding inequities and the growth of poverty within the state (MassBudget, 2012). While MCAS may help identify the consequences of inequities, its high-stakes uses exacerbate these consequences. These MCAS problems include but are not limited to:

Disparate impact on students. Numerous studies document that the use of high-stakes testing ? including test barriers to high school graduation ? bears adverse impact on students and is accompanied by widening racial/ethnic and income-based gaps.? MCAS testing has not significantly reduced disparities in achievement or eliminated gaps, thus the negative consequences of the high-stakes tests fall disproportionately on the groups that most need help. In Massachusetts? low-income, urban districts, large numbers of students perform below proficiency on the MCAS. Twice as many urban as suburban public high school graduates fail college placement tests in math and English and must take noncredit, remedial classes (Massachusetts DESE, 2008). Results on the National Assessment of Educational Progress (NAEP) show a failure to achieve significant reduction in the achievement gap separating Massachusetts? white students from African-American and Latino students since 2003. The negative effects of our high-stakes testing environment are perhaps most pronounced for English Language Learners (ELLs) ? for whom the tests were not designed ? who cumulatively and consistently fail to achieve proficiency within the limited school time of a year and a day before they are required to take the exam in English. According to a 2011 Gaston Institute report, ?In high school, about 18% of [ELL] students were retained in grade, many of them several times and many of them in the ninth grade to avoid having them fail the tenth grade MCAS graduation requirement.? In Massachusetts, ELLs are, on average, nine times more likely to drop out of high school than their peers. The disparate impact of the graduation requirement on students with disabilities also is striking. For example, of the 2,798 students who did not pass all the required MCAS tests by the end of their senior year in 2011, 75% were students with disabilities. The fact remains that Massachusetts has placed the most severe accountability on the backs of its most disadvantaged students.

Negative impact on curriculum and instruction. Surveys of teachers in Massachusetts (Abrams et al., 2003; Clarke et al., 2003) and nationally (McMurrer, 2007; Moon et al., 2003; Hinde, 2003) show a marked increase in teaching to the test and narrowing the curriculum to tested subjects as a result of high-stakes testing. In addition, research compiled by the NRC and others shows this comes with a negative impact on school climate, often creating an environment of intimidation, fear, anxiety and stress for both teachers and their students, including kindergarten children (Hout & Elliott, 2011). Further, investigators of the Atlanta cheating scandal identified high-stakes testing as a cause of the problem (Georgia Bureau of Investigation, 2011). Under such conditions, it becomes difficult for teachers to create a learning environment that promotes creativity, critical thinking, risk-taking, experimentation and a love of learning. Moreover, as with other negative consequences, there is a disparate impact: teaching to the test, curricular narrowing and damaging school climates more frequently affect low income and minority students.

Negative impact on educators. High-stakes testing creates adverse consequences not only for students but also for educators. Researchers have challenged the validity, reliability, effectiveness, and ethics of using high-stakes test scores to evaluate educators. Further, as argued in an open letter to Mayor Rahm Emanuel by Chicagoland Researchers and Advocates for Transformative Education (CReATE, 2012), ?There is no evidence that evaluation systems that incorporate student test scores produce gains in student achievement? [and] Teachers will subtly but surely be incentivized to avoid students with health issues, students with disabilities, students who are English Language Learners, or students suffering from emotional issues. Research has shown that no model yet developed can adequately account for all of these ongoing factors.? Student growth measures are not capable of identifying with reasonable accuracy and consistency over time who is or is not an effective teacher. Already some highly effective teachers are leaving the profession. Further, Massachusetts? new system requires that ?measures of student learning? be developed as part of annually evaluating every teacher in every subject and grade. This could further inundate students with testing and test preparation.

Negative impact on schools. The problems discussed above harm many schools, as well as their students and teachers individually.? While federal law requires assessments, it does not require high-stakes standardized testing. There is nothing to prevent Massachusetts from using a very different assessment system, using multiple sorts of indicators gathered over time, as was proposed in the Education Reform Act of 1993.

Recommendations

Because of these and other problems with the high-stakes uses of standardized tests to evaluate students, teachers and schools, we call on the Board of Elementary and Secondary Education to:

  • Work with educators, parents and the public to craft a new assessment system that will more fully assess the many competencies our children need to succeed in the 21st century and that will avoid the current overreliance on standardized tests.
  • Stop using MCAS test results as a barrier to high school graduation.
  • Prohibit the use of test scores in educator evaluations and in decisions for hiring, firing, laying off or rewarding teachers.
  • Focus teacher evaluations on the appropriate use of evidence-based teaching practices and a comprehensive set of indicators of classroom and school-based student learning rather than one-shot test scores.
  • Stop using test scores to designate schools for punitive turnaround reform measures that mandate the firing of 50% or more of the staff.
  • Focus turnaround reform efforts on school-wide, research-based approaches.

We know that reforming the current high-stakes testing system will take time and political capital, but we believe that it is not only possible but also imperative if we want to improve the lives of all children and ensure their future success. Given the recent unprecedented attention focused on problems with current testing practice, this is exactly the right time to transform recommendations into reality. Therefore, we make ourselves available to the BESE to assist in these efforts in whatever ways are necessary.

Massachusetts Professors and Researchers

Statement on High-Stakes Testing

Endorsers

1. Jorgelina Abbate-Vaughn, UMass Boston

2. Laura Baker, Assistant Professor, Westfield State University

3. Nancy Carlsson-Paige, Professor Emerita, Lesley University

4. Steve Cohen, Education Department, Tufts University

5. Eric DeMeulenaere, Ph.D., Clark University
6. Robin DiAngelo, Ph.D., Westfield State University

7.? R. Clarke Fowler, Coordinator of Early Childhood Education, Salem State University

8. Ken Haar, Associate Professor, Associate Vice President for Government Relations, Westfield State University

9. Vanessa?Holford Diana, Westfield State University

10. Chris Gallagher, Northeastern University

11. Lisa Guisbond, FairTest

12. Jim Horn, Professor, Cambridge College

13. Jonathan King, MIT

14. Trudy Knowles, Ed. D., Westfield State University

15. Louis Kruger, Northeastern University

16. Diane Levin, Wheelock College
17. Aviva Liebert, Ph.D., Framingham State University
18. George Madaus, Boisi Professor of Education and Public Policy Emeritus at Boston College

19. Robin Marion, Westfield State U.

20. James E. McDermott, Ed. D., Assistant Professor, Jacob Hiatt Center for Urban Education, Clark University

21. Terry Meier, Associate professor of education, Wheelock College
22. Edward Miller, Wellfleet, Mass.; teacher and writer; former editor,?Harvard Education Letter

23. Linda Nathan, Ex. Director, Center for Arts in Education, Boston Arts Academy, Founding Headmaster, Boston Arts Academy.

24. James Nehring, Associate Professor, Graduate School of Education, UMass/Lowell

25. Monty Neill, Ed.D., FairTest

26. Floriz Wilma Ortiz, Westfield State University

27. Leigh Patel, Boston College

28. Erika Pilver, Westfield State University

29. Ricardo D. Rosa ? University of Massachusetts ? Dartmouth / Department of Educational Leadership & Policy Studies

30. Dennis Shirley, Boston College Lynch School of Education
31. Elizabeth Stassinos PhD, Associate Professor of Anthropology, Westfield State University

32. Amanda Walker Johnson, UMass-Amherst

Initiators

Chris Buttimer, Ph.D. candidate, Harvard Graduate School of Education

Nancy Carlsson-Paige, Professor Emerita, Lesley University

Lisa Guisbond, FairTest and Citizens for Public Schools

Monty Neill, Executive Director, FairTest

References

AERA, 2000. AERA Position Statement on High-Stakes Testing in Pre-K ? 12 Education. http://www.aera.net/AboutAERA/AERARulesPolicies/AERAPolicyStatements/PositionStatementonHighStakesTesting/tabid/11083/Default.aspx

Abrams, L.M., Pedulla, J.J., & Madaus, G.F. 2003. Views from the classroom: Teachers? opinions of statewide testing programs.?Theory into Practice 42(1), 18-29.

Baker, E. et al. 2009. ?Problems with the Use of Student Test Scores to Evaluate Teachers,? Economic Policy Institute Briefing Paper. Available at http://epi.3cdn.net/b9667271ee6c154195_t9m6iij8k.pdf

Clarke et al. 2003. Perceived Effects of State-Mandated Testing Programs on Teaching and Learning: Findings from Interviews with Educators in Low-, Medium-, and High-Stakes States. Boston: NBETTP. Available at http://www.bc.edu/research/nbetpp/reports.html

CReATE, 2012. ?Misconceptions and Realities about Teacher and Principal Evaluation.? Available at http://createchicago.blogspot.com/2012/03/misconceptions-and-realities-about.html

Uriarte, M., et al. (2011, November). Improving educational outcomes of English Language Learners in schools and programs in Boston Public Schools. Boston, MA: Mauricio Gast?n Institute. Available at: http://www.ccebos.org/ell_Uriarte_et_al_2011_Executive_Summary.pdf

Georgia Bureau of Investigation (GBI). 2011. Special Investigation into CRCT Cheating at APS. Available at http://www.atlanta.k12.ga.us/cms/lib/GA01000924/Centricity/Domain/44/APS_CRCT_-_vol3_-_28455206.pdf

Hinde, E. R. 2003, May 27. The tyranny of the test: Elementary teachers? conceptualizations of the effects of state standards and mandated tests on their practice. Current Issues in Education [On-line], 6(10). Available at http://cie.ed.asu.edu/volume6/number10/

Hout, M. and Elliott, S.W. Editors. 2011. Incentives and Test-Based Accountability in Education (Washington, D.C.: National Academies Press), 30. Available at? http://www.nap.edu/catalog.php?record_id=12521.

Koretz, D. M. (2008). Measuring up: What educational testing really tells us. Cambridge, MA: Harvard University Press.

Massachusetts Budget and Policy Center. 2011. ?2010 Poverty Rate Increases in Both Massachusetts and Across the Country.? http://www.massbudget.org/report_window.php?loc=PovertyFacts_9.22.11.html

Massachusetts Department of Elementary and Secondary Education, 2008.

Massachusetts School-to-College Report High School Class of 2005. Available at www.doe.mass.edu/research/reports/0208bhe.pdf

McMurrer, J. 2007. Choices, changes, and challenges: Curriculum and instruction in the NCLB era. Washington, DC: Center on Education Policy.

Moon, T. R., Callahan, C. M., & Tomlinson, C. A. 2003, April 28. Effects of state testing programs on elementary schools with high concentrations of student poverty-good news or bad news? Current Issues in Education, 6(8). Available at? http://cie.ed.asu.edu/volume6/number8/

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